Ritchie Ho, PhD
Principal Investigator

Ritchie is an Assistant Professor and Research Scientist in the Center for Neural Sciences and Medicine at Cedars-Sinai Medical Center. Born and raised in Los Angeles, he obtained his undergraduate degree in Molecular Cell Biology at UC Berkeley. He initiated his career in biomedical science as a technician at Caltech with Dr. David Anderson researching neurodevelopment. Seeking to eventually establish his own creative lines of investigation, he pursued his doctoral training at UCLA with Dr. Kathrin Plath, studying mechanisms regulating cellular reprogramming. During his postdoctoral training at Cedars-Sinai with Dr. Clive Svendsen, he qualified the ability of iPSCs and transgenic animals to model human development, aging, and neurodegeneration. He is now directing his independent research program and working with the talented individuals that follow…

Stefano Arfè, PhD
Postdoctoral Scientist

Stefano earned an MSc in Medical Biotechnologies from the University of Naples ‘Federico II’, Italy. He started his scientific journey working in Dr. Luciano Di Croce’s lab at the CRG Institute in Barcelona where he characterized accessory proteins of the Polycomb complex involved in mammalian embryogenesis. He then spearheaded his PhD research project in Dr. Geneviève Almouzni’s lab at the Curie Institute Research Center in Paris to elucidate the dynamics of histone H3 variants during embryonic stem cell differentiation at the single-molecule level using super-resolution microscopy and high-throughput sequencing assays. By applying his expertise in chromatin and epigenetics applied to stem cells, Stefano joins the Ho Lab to deepen molecular mechanisms arising from disease models of neuronal aging and ALS.

Ashley Dawson
Research Associate I

Ashley graduated from University of California, Riverside with a Bachelor of Science in Neuroscience. While at UCR, she worked in the Santhakumar Lab researching traumatic brain injury, specifically looking at the role of toll-like recepter 4 (TLR4) on synaptic inhibition in the normal versus the injured brain. In the Ho Lab, Ashley is characterizing transgenic C9orf72 animals for behavioral deficits and neuropathology in response to CRISPRi gene therapy candidates.

Esha Gauba, PhD
Postdoctoral Scientist

Esha earned her master’s and Ph.D. in Molecular and Cell Biology at the University of Texas at Dallas. During her Ph.D., she identified mechanistic insights in mitochondrial pathways underlying neurodegeneration in both aging brains and Alzheimer’s Disease. She then pursued her postdoctoral training in the lab of Dr. Katrin Andreasson at Stanford University as a SPARK scholar, where she studied the role of the de novo NAD+ synthesis pathway in innate immune cells leading to inflammaging & dementia. Esha joined the Ho Lab with a deep interest in leveraging her training to utilize multi-omics data and iPSC technology to identify key cellular and molecular modifiers of aging that lead to various neurodegenerative disorders like ALS.

Nathan Molayem
Research Associate I

Nathan completed his undergraduate education in Biology at the University of California Santa Barbara, where he engaged in botanical and neurology research. After graduating, Nathan went on to study the concept of translational read-through regarding nonsense mutations at Tel Aviv University. Nathan earned his Master’s in Stem Cell Biology and Regenerative Medicine shortly after, where he focused on generating CAR-M cells with Dr. Qilong Ying. Nathan now works with the Ho Lab on using CRISPRi to silence C9orf72 hexanucleotide repeat expansions causing ALS.

Michael Edison Ramos
Graduate Student

Michael completed his undergraduate education in Biology at California State University, San Bernardino, where he developed an interest in stem cells and regenerative medicine. He then worked as a laboratory technician at Cedars-Sinai Medical Center where he received specialized training in the use of induced pluripotent stem cells (iPSC) to study neurodegeneration and pancreatic disorders. He joined the Ho Lab as a graduate student to study the genetic programs involved in aging.

Oksana Shelest, MS
Senior Behavioral Scientist

Oksana earned her master’s degrees in Neuroscience from Moscow State University in Russia and in Chemistry from Kharkov State University in Ukraine. She has extensive experience in animal surgery and in vivo electrophysiology as well as in animal colony management and behavioral testing in disease and drug addiction models. She is passionate about working towards understanding nature, one of the greatest human abilities, and she studies animal behavior in the context of human neurological disorders.

Brijesh Singh, PhD
Postdoctoral Scientist

Brijesh earned his master’s in Biochemistry at the University of Allahabad, India and pursued doctoral studies in neuroscience from the National Brain Research Center, India. He explored the novel role of UBE3A, a ubiquitin E3 ligase in the pathogenesis of Alzheimer’s disease. To further his research skills, he moved to Columbia University to advance his career as a postdoctoral research scientist under the supervision of Dr. Alejandro Chavez, where he focused on developing CRISPR/Cas9-assisted tools, specifically high-throughput gene knock-in technologies and targeted mutations to explore subcellular phenotypes in neurodegenerative disease. In the Ho Lab, Brijesh will be leading CRISPR-engineered neuron maturation and aging projects to model iPSCs for sporadic neurodegenerative diseases like Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS).

Ian Tindel
Research Associate I

Ian completed his undergraduate degree in Biology from California State University, Los Angeles (CSULA), with a minor in Computer Science. He has previously engaged in research on wing imaginal disc development at CSULA and osteoarthritic clinical data at the VA Greater Los Angeles Health Care System. He is currently analyzing the declining motor behavior of aging wild type and ALS mice.

Former Members